Get to know! "Premature Aging Disease" is a one-in-a-million abnormal cell disease.

Health News

20 Jun 2024

Get to know! "Premature Aging Disease" is a one-in-a-million abnormal cell disease.

      Progeria, or Hutchinson-Gilford Progeria Syndrome (HGPS), is an extremely rare condition affecting only 1 in 8 million people worldwide. Approximately 90% of cases are caused by a mutation in the Lmna gene, leading to abnormal synthesis of the protein laminA. This genetic disorder results in rapid aging of cells and genes, far beyond the normal aging process. Initially, affected children might just be slightly underweight, but by ages 1-2, their growth and physical and cognitive development start to lag significantly. Today, we share the symptoms of "Progeria."

  • Extremely slow growth, stunted stature, low weight, rapid aging, and easy fatigue.
  • Wrinkled skin, appearance much older than actual age, high-pitched voice.
  • Thin skull, disproportionate head, small jaw, and face.
  • Hair and body hair loss, delayed and easily lost teeth, abnormal nails (thin, short, or absent), osteoporosis, and joint pain.
  • Average life expectancy is around 13 years, with death often resulting from heart disease and other organ failures, such as heart failure and arterial stiffening in the brain.

      Currently, there is no cure for Progeria. Treatment focuses on managing symptoms and overall health. Lmna testing can be performed to check for mutations at the molecular level in pregnant women. Preventive measures are limited, but parental health checks and preconception planning may help identify some genetic abnormalities that could affect offspring. However, it is not possible to guarantee detection of all conditions.


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